Informatics Publishing Limited

M. D. Shende ¹, N. R. Dighade ¹, A. V. Kasture ²

Affiliations
1 Adv. V. R. Manohar Institute of Diploma in Pharmacy, Wanadongri, Hingna Road, Nagpur–441110, IN
2 Department of Pharmaceutical Sciences, Rashtrasant Tukdoji Maharaj Nagpur University, Nagpur, IN

Abstract

Cinitapride and Pantoprazole are available as capsule dosage forms in the ratio 1:13.33. A simple reproducible and efficient method for the simultaneous determination of cinitapride and pantoprazole in marketed formulation was developed. The proposed method is based on the Q-analysis UV-Spectrophotometric method. The absorbance maximum of cinitapride and pantoprazole were found to be 265.5 nm and 268 nm respectively in water. In Q-analysis, the isoabsorptive point for both the drugs was found at 236 nm. The linearity range lies between 5-30 μg/ml for cinitapride and pantoprazole at their respective wavelengths. Both the drugs obey Beers law. The recovery studies confirmed the accuracy of the proposed method.

Keywords

Pantoprazole, Cinitapride, Q-analysis, Simultaneous Estimation

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A. P. Sherje ¹, A. V. Kasture ²

Affiliations
1 STES's Sinhgad Institute of Pharmacy, S. No. 49/1, Off Westerly Bypass, Pune-Mumbai Expressway, Narhe, Pune-411 041 (M.S.), IN
2 Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha- 442 001 (M.S.), IN

Abstract

A simple and precise HPLC method has been developed for simultaneous quantitation of lansoprazole and domperidone in pharmaceutical formulations. The chromatographic separation was achieved at ambient temperature using an Intersil C₁₈ (4.6 × 250 mm, 10 μm) column using a mobile phase comprising of 0.1 M sodium acetate and acetonitrile (55: 45 v/v), pH adjusted to 7.0 with orthophosphoric acid. The retention times for lansoprazole and domperidone were 5.78 min and 3.77 min respectively. The mean recoveries from the capsule formulations were between 99-101%. The detector response was found to be linear in the concentration range of 24-36 μg/mL for lansoprazole and 8-12 μg/mL for domperidone. The developed method herein described can be employed for quality control and routine analysis of drugs in capsule formulation.

Keywords

Lansoprazole, Domperidone, Quantitation, RP-HPLC.

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R. W. Lohe ¹, P. B. Suruse ¹, M. K. Kale ¹, P. R. Barethiya ², A. V. Kasture ², S. W. Lohe ³

Affiliations
1 Kamla Nehru College of Pharmacy, Butibori, Nagpur-441108 (MS), IN
2 Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha-442001 (MS), IN
3 Anurag College of Pharmacy, Warthi, Bhandara (MS), IN

Abstract

Two simple, accurate, economical and reproducible spectrophotometric methods for simultaneous estimation of Rabeprazole and Diclofenac in combined tablet dosage form have been developed. The first developed method employs formation and solving of simultaneous equation using two wavelengths 294.0 nm and 281.2 nm for formation of simultaneous equation. Second developed method involves graphical absorbance ratio, using two wavelengths. Both of these methods obey Beer’s law in the employed concentration ranges for respective methods. Results of analysis were validated statistically and by recovery studies.

Keywords

Spectrophotometric Estimation, Rabeprazole, and Diclofenac.

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